N-Acetyl Selank Amidate

N-Acetyl Selank Amidate is a synthetic derivative of the heptapeptide selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) that carries an acetyl group on the N-terminal threonine amine and an amide in place of the C-terminal proline carboxyl group. The parent peptide was synthesized as an analog of the endogenous peptide tuftsin and ends in the Pro-Gly-Pro motif shared by the glyproline family of regulatory peptides.

N-Acetyl Selank Amidate in the research literature

A PubMed search found no abstracts that examine the N-acetylated, C-amidated form of selank directly, so the available data describe the unmodified parent. In radioligand binding assays on brain membrane preparations, selank acted as a positive allosteric modulator of [3H]GABA binding. In rats with long-term ethanol exposure, ex vivo measurements showed that hippocampal and frontal cortex BDNF content in selank-exposed animals lacked the rise seen with ethanol alone. In blood plasma, the parent peptide was broken down mainly to Thr-Lys-Pro-Arg-Pro, Thr-Lys-Pro, Arg-Pro and Gly-Pro. Whether the terminal modifications change any of these properties has not been reported in the abstracts reviewed.