For laboratory research use only — not for human or veterinary use. Not evaluated by the U.S. FDA.
Metabolic Peptide
Adipotide (FTPP)
A peptidomimetic pairing a prohibitin-targeting motif with a pro-apoptotic sequence, studied in animal models as a tool for targeting the vasculature of white adipose tissue.
Size
Quantity
$39.99
Bundle & save
Order by 3:00 PM ET for same-day dispatch
Cutoff 3:00 PM ET · same-day dispatch
Estimated arrival in 2 business days
Overnight shipping available
Free shipment protection included
Adipotide (FTPP)
1 × 5mg · $39.99
99% purity, QC passed
HPLC + mass-spec verified
Shipment protection
Free on every order
Free shipping over $150
Same-day dispatch before 3PM ET
About Adipotide (FTPP)
Structure and research context
Adipotide, also catalogued as prohibitin-TP01 or FTPP, is a ligand-directed peptidomimetic with the sequence CKGGRAKDC-GG-D(KLAKLAK)2. It joins two functional modules through a diglycine linker: the CKGGRAKDC motif, isolated by in vivo phage display as a peptide that homes to the vasculature of white adipose tissue and associates with the multifunctional membrane protein prohibitin, and a pro-apoptotic (KLAKLAK)2 domain built from D-amino acids. The conjugate has the formula C111H206N36O28S2 and a molar mass of about 2,557 g/mol.
Adipotide (FTPP) in the research literature
The founding mouse work established prohibitin as a vascular marker of white adipose tissue and used the CKGGRAKDC motif to direct a pro-apoptotic peptide to prohibitin in the adipose vasculature. Studies in monkeys spanning three species later reported that adipotide induced targeted apoptosis within blood vessels of white adipose tissue, and they characterized predictable, reversible changes in renal proximal tubule function.
More recent medicinal chemistry has engineered next-generation prohibitin-targeting peptides, including a mixed-chirality variant of prohibitin-TP01 substituted with D-arginine, D-(RLARLAR)2, designed to increase stability. That work, conducted in a diet-induced mouse model, proposed mitochondrial uncoupling as a mechanism for the newer analogues.
Summarized from peer-reviewed literature for research context only; not a product claim. PubMed: 15133506 · 22072637 · 40591817
Frequently researched together
Commonly studied alongside Adipotide (FTPP).
Compound information
Technical specifications
Molecular profile
| Type | Pro-apoptotic peptidomimetic (CKGGRAKDC-GG-D(KLAKLAK)2) |
| CAS number | 859216-15-2 |
| Molecular weight | 2557.2 g/mol |
| Formula | C111H206N36O28S2 |
Storage & stability
- ❄️
Lyophilized (powder)
-20°C · stable 2+ years
- ❄️
Reconstituted
2–8°C · use within 30 days
Adipotide (FTPP) sources & references
Peer-reviewed literature, for research context
- Science translational medicine
A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys
2011·DOI: 10.1126/scitranslmed.3002621·PMID: 22072637Barnhart KF, Christianson DR, Hanley PW, Driessen WH, Bernacky BJ, Baze WB
View source - Nature medicine
Reversal of obesity by targeted ablation of adipose tissue
2004·DOI: 10.1038/nm1048·PMID: 15133506Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W
View source - Journal of the American Chemical Society
Mixed-Chirality Prohibitin Peptide: D-(RLARLAR)2 Enhances Stability and In Vivo Effects on Obesity
2025·DOI: 10.1021/jacs.5c05536·PMID: 40591817Chan LY, Weger BD, Weger M, Du J, Lawrence N, Cardoso MH
View source
More in Metabolic
Every Metabolic research compound in the catalog.
Important research notice
Not for human consumption. This product is sold exclusively for laboratory and in vitro research. It is not intended to diagnose, treat, cure, or prevent any disease.
Any research findings referenced on this page are drawn from published, peer-reviewed literature and are provided for educational context only. They are not product claims and should not be read as medical advice.
By purchasing, you confirm you are a qualified researcher and will handle this material in accordance with all applicable laws and institutional guidelines.