For laboratory research use only — not for human or veterinary use. Not evaluated by the U.S. FDA.
Peptide Bioregulator
Livagen
A short synthetic peptide from the Khavinson bioregulator series, studied in preclinical models for peptide signaling in hepatic tissue and for effects on chromatin structure in cell culture.
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$59.99
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Livagen
1 × 20mg · $59.99
99% purity, QC passed
HPLC + mass-spec verified
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About Livagen
Structure and research context
Livagen is a synthetic tetrapeptide from the Khavinson bioregulator series with the sequence Lys-Glu-Asp-Ala (KEDA; formula C18H31N5O9, molecular weight 461.5 g/mol, CAS 433257-50-2). Its developers report that the sequence was obtained by directed chemical synthesis based on amino acid analysis of liver polypeptide preparations. Biochemical work has characterized it as a weakly hydrolyzed peptide, with small-intestinal peptide hydrolases reported not to cleave it even to a small extent.
Livagen in the research literature
In monolayer cultures of rat hepatocytes, Livagen was reported to increase the level of protein synthesis and the amplitude of its rhythmic fluctuations, with the largest changes in cells from older animals. An organotypic liver culture study examined immunocytochemical and morphometric parameters of the cell populations. In vitro, the peptide reduced glycyl-L-leucine dipeptidase activity in small-intestinal preparations by about 50%.
Cytogenetic studies in cultured lymphocytes have examined Livagen among several short peptides for effects on chromatin, including decondensation of heterochromatin and activity of ribosomal genes in nucleolar organizer regions.
Summarized from peer-reviewed literature for research context only; not a product claim. PubMed: 15926314 · 16075683 · 12577697 · 37042594
Livagen Certificate of Analysis
Third-party tested · Independent analytical lab
20mg
99.48%latest
| Tested | Measured | Purity |
|---|---|---|
| Dec 2025 | 24.82mg | 99.48% |
Frequently researched together
Commonly studied alongside Livagen.
Compound information
Technical specifications
Molecular profile
| Type | Synthetic tetrapeptide bioregulator |
| CAS number | 433257-50-2 |
| Molecular weight | 461.5 g/mol |
| Amino acids | 4 |
| Sequence | Lys-Glu-Asp-Ala |
| Formula | C18H31N5O9 |
Storage & stability
- ❄️
Lyophilized (powder)
-20°C · stable 2+ years
- ❄️
Reconstituted
2–8°C · use within 30 days
Livagen sources & references
Peer-reviewed literature, for research context
- Advances in gerontology = Uspekhi gerontologii
[Functional morphology of an organotypic liver culture exposed to the peptide livagen]
2002·PMID: 12577697Riadnova IIu, Filippov SV, Iuzhakov VV
View source - Advances in gerontology = Uspekhi gerontologii
[The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology.]
2020·PMID: 32362099Kuznik BI, Khasanova NB, Ryzhak GA, Mezsheriakova IE, Khavinson VK
View source
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Important research notice
Not for human consumption. This product is sold exclusively for laboratory and in vitro research. It is not intended to diagnose, treat, cure, or prevent any disease.
Any research findings referenced on this page are drawn from published, peer-reviewed literature and are provided for educational context only. They are not product claims and should not be read as medical advice.
By purchasing, you confirm you are a qualified researcher and will handle this material in accordance with all applicable laws and institutional guidelines.